The computational counterpart of the cs model is called immsim which stands for immune system simulator immsim was written in 1992 by the physicist phil e seiden and the immunologist franco celada this model was built around the idea of developing a computerized system to perform experiments similar in vivo experiments a tool developed to help biologists testing theories and hypothesis about how the immune system works. The computational counterpart of the cs model is called immsim which stands for immune system simulator immsim was written in 1992 by the physicist phil e seiden and the immunologist franco celada this model was built around the idea of developing a computerized system to perform experiments similar in vivo experiments a tool developed to help biologists testing theories and hypothesis about how the immune system works c immsim is best viewed as a collection of models in a single . The computational counterpart of the cs model is called immsim which stands for immune system simulator immsim was written in 1992 by the physicist phil e seiden and the immunologist franco celada this model was built around the idea of developing a computerized system to perform experiments similar in vivo experiments a tool developed to help biologists testing theories and hypothesis about how the immune system works. We introduce the basic immune simulator bis an agent based model created to study the interactions between the cells of the innate and adaptive immune system innate immunity the initial host response to a pathogen generally precedes adaptive immunity which generates immune memory for an antigen the bis simulates basic cell types mediators and antibodies and consists of three virtual spaces representing parenchymal tissue secondary lymphoid tissue and the lymphatic . The main areas covered include immune system modeling blood vessel dynamics cancer modeling and treatment and epidemiology the chapters address topics that are at the forefront of current biomedical research such as cancer stem cells immunodominance and viral epitopes aggressive forms of brain cancer or gene therapy the presentations highlight how